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    1. Neuroscience

    Motor Systems: Variability in neural networks

    Daniel R Kick, David J Schulz
    Experiments on neurons in the heart system of the leech reveal why rhythmic behaviors differ between individuals.
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    1. Cancer Biology

    Cancer Risk: Why do women with melanoma do better than men?

    Keiran SM Smalley
    Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.
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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
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    1. Developmental Biology
    2. Evolutionary Biology

    Development: Transforming a transcription factor

    Robert D Burke
    A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
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    1. Cell Biology

    Receptors: How low can you go?

    H Steven Wiley
    Extremely low numbers of active epidermal growth factor receptors are sufficient to drive tumor growth.
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    1. Developmental Biology

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
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    1. Ecology
    2. Plant Biology

    Pollination: Solar flower power

    Julia Bing, Danny Kessler
    Bumblebees use invisible temperature patterns on flowers to make foraging decisions.
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    1. Evolutionary Biology

    Sex Chromosome Evolution: Culture shock

    Antoine Molaro, Harmit S Malik
    Many different human cell lines, including both normal and cancer cells, appear to converge to a state that contains an unusual number of chromosomes when they are grown in culture.
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    1. Cell Biology

    Epigenetics: How does obesity lead to insulin resistance?

    Chan Hee J Choi, Paul Cohen
    Experiments on mice show that an enzyme called DNA methyltransferase 3a is involved in insulin resistance via an epigenetic mechanism.
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    1. Biochemistry and Chemical Biology

    Intracellular Diffusion: How bacteria keep proteins moving

    Conrad W Mullineaux
    Bacteria contain large numbers of negatively-charged proteins to avoid the electrostatic interactions with ribosomes that would dramatically reduce protein diffusion.
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