Browse our Research Advances

Page 44 of 52
    1. Neuroscience

    Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range

    Christian Keine, Rudolf Rübsamen, Bernhard Englitz
    Inhibition reduces the neuronal representation of acoustic signals to enhance temporal precision in the auditory brainstem.
    1. Neuroscience

    Preconditioned cues have no value

    Melissa J Sharpe, Hannah M Batchelor, Geoffrey Schoenbaum
    Preconditioned cues provide information about an associative model but do not, by default, trigger representations of value, either model-based or model-free.
    1. Neuroscience

    Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila

    Stefanie Hampel, Claire E McKellar ... Andrew M Seeds
    A grooming sequence is produced by a neural architecture that readies different movements simultaneously, and a mechanism where prioritized suppression between the movements determines their sequential performance.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

    Eric A Prinslow, Chad A Brautigam, Josep Rizo
    Isothermal titration calorimetry experiments clarify apparently discrepant results described previously and show that N-terminal sequences of complexin bind to SNARE complexes containing C-terminally truncated synaptobrevin when they include the syntaxin-1 juxtamembrane region.
    1. Neuroscience

    A common directional tuning mechanism of Drosophila motion-sensing neurons in the ON and in the OFF pathway

    Juergen Haag, Abhishek Mishra, Alexander Borst
    A common mechanism for computation of direction selectivity in the ON and OFF channel is demonstrated.
    1. Neuroscience

    Increasing suppression of saccade-related transients along the human visual hierarchy

    Tal Golan, Ido Davidesco ... Rafael Malach
    Similar to spontaneous eye blinks perceptual stability, despite small saccades, is related to actively silencing transients in the high-level ends of both ventral and dorsal visual cortices, while activity in low-level visual cortex remains unstable.
    1. Neuroscience

    Circular oligomerization is an intrinsic property of synaptotagmin

    Jing Wang, Feng Li ... James E Rothman
    Calcium-binding synaptotagmins are involved in ring oligomer formation, which allows synaptotagmins to synchronize neurotransmitter release to Ca2+ influx.
    1. Neuroscience

    Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

    Zuzanna Brzosko, Sara Zannone ... Ole Paulsen
    Sequential neuromodulation by acetylcholine and dopamine enables correlational synaptic learning which, when incorporated into a computational model, yields effective navigation toward changing reward locations as in natural foraging behavior.
    1. Neuroscience

    Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila

    Zachary A Knecht, Ana F Silbering ... Paul A Garrity
    The neurons and receptors mediating moist air detection in Drosophila are identified, revealing that moist and dry air detection depend on overlapping Ionotropic Receptors and that these pathways are both critical for hygrosensation.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu, Alanna Klose ... Joe V Chakkalakal
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.