Browse our Short Reports

Page 43 of 64
    1. Biochemistry and Chemical Biology

    A reverse transcriptase ribozyme

    Biswajit Samanta, Gerald F Joyce
    An RNA enzyme is shown to function as a reverse transcriptase, an activity thought to be crucial for the transition from RNA to DNA genomes during the early history of life on Earth.
    1. Neuroscience

    Local processing in neurites of VGluT3-expressing amacrine cells differentially organizes visual information

    Jen-Chun Hsiang, Keith P Johnson ... Daniel Kerschensteiner
    Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.
    1. Neuroscience

    The human auditory brainstem response to running speech reveals a subcortical mechanism for selective attention

    Antonio Elia Forte, Octave Etard, Tobias Reichenbach
    Selective attention to one of two speakers consistently modulates the response of the human auditory brainstem to each speaker's pitch.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

    Mattia Volta, Dayne A Beccano-Kelly ... Austen J Milnerwood
    LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

    Jaclyn E Quin, Ioana Bujila ... Ann-Kristin Östlund Farrants
    Examining gene expression in the Fulani, an ethnic group relatively protected from malaria, identifies a more transcriptionally reactive response in cells of the innate immune system.
    1. Neuroscience

    Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

    Martina Absinta, Seung-Kwon Ha ... Daniel S Reich
    Meningeal lymphatic vessels are present in human and nonhuman primates (common marmoset monkeys) and they can be noninvasively imaged and mapped in vivo with high-resolution, clinical MRI.
    1. Stem Cells and Regenerative Medicine

    Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration

    Grant Parker Flowers, Lucas D Sanor, Craig M Crews
    CRISPR-based lineage tracing in the axolotl shows that regenerated limbs are composed of the same cell lineages in the same frequencies as those that gave rise to the original limb.
    1. Neuroscience

    Unusual prism adaptation reveals how grasping is controlled

    Willemijn D Schot, Eli Brenner, Jeroen BJ Smeets
    Adapting single-digit movements in opposite directions makes people open their grip in accordance with the adaptations of the individual digits, showing that grip aperture arises from goal-directed movements of the digits rather than being controlled independently.
    1. Neuroscience

    Thalamic input to auditory cortex is locally heterogeneous but globally tonotopic

    Sebastian A Vasquez-Lopez, Yves Weissenberger ... Johannes C Dahmen
    Layers 1 and 3b/4 of auditory cortex receive surprisingly heterogeneous but tonotopically matching input from the thalamus.
    1. Neuroscience

    Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior

    Salvatore Lecca, Frank Julius Meye ... Manuel Mameli
    Glutamatergic signaling from the lateral hypothalamus instructs lateral habenular neurons for encoding aversive external stimuli to subsequently guide escape behaviours.