The role of genetically identified V3 interneurons with ascending propriospinal projections in the spinal locomotor circuitry and their contribution to the limb coordination and speed-dependent gait expression during locomotion were investigated using a combination of experimental studies and computational modeling.
Short-term monocular deprivation effects are widespread in the visual cortex and extend subcortically to the ventral pulvinar, while sparing the dorsal pulvinar and the lateral geniculate nucleus.
Manindra Bera, Sathish Ramakrishnan ... James E Rothman
Complexin, in conjunction with Synaptotagmin, clamps the SNARE-assembly process under resting conditions and promote vesicle fusion in response to calcium signal.
TRACC (Transcriptional Readout Activated by Cell-cell Contacts) is an engineered molecular tool that detects and records cell-cell contacts in mammalian systems.
Deep mutagenesis experiments demonstrate that while cancer-causing mutations in Ras selectively alter regulatory interactions with GTPase-activating proteins, Ras is also activated by many mutations that decrease protein stability.
Computational modelling predicts spatial segregation of different types of nuclear transport receptors in assemblies of nuclear pore proteins, lending support to the idea of separate transport pathways in the nuclear pore complex as a way to enhance transport efficiency.
Effective navigation of odor plumes in the wild requires that animals sense multiple temporal aspects of odor signals, which are encoded naturally by neurons in the fly olfactory circuit.
