Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
DunedinPACE is a novel DNA methylation biomarker of the pace of biological aging for intervention trials and natural experiment studies investigating how the rate of aging may be changed by behavioral or drug therapy, or by environmental modification.
Genetic analysis and biochemical approaches reveal that chemorefractory properties are reversed by inhibiting mucin secretion, thus providing a means to curb the growth and spread of colorectal cancer.
Matthew W Parker, Jonchee A Kao ... Michael R Botchan
The intrinsically disordered regions (IDRs) of metazoan DNA replication licensing factors phase separate through synergistic electrostatic DNA-IDR and hydrophobic inter-IDR interactions.
Pupil diameter cannot accurately predict spiking activity in the locus coeruleus on a moment-by-moment basis, and exhibited large fluctuations to identical stimulation in the LC.
The metal-dependent protein phosphatase Nilkantha, a Drosophila PPM1A/B homolog, dephosphorylates Acinus thereby restraining starvation-independent autophagy.
The copy-and-shift mechanism modelled in the insect central complex facilitates multimodal navigation, providing a general computation model explaining flexible navigation behaviours.
Maia Kinnebrew, Giovanni Luchetti ... Rajat Rohatgi
Cholesterol accessibility in the plasma membrane can be controlled by proteins and function as a signaling messenger in cell-cell communication pathways.
Visual sensitivity to correlation patterns in rats matches that previously measured in humans, as well as predictions from efficient coding theory based on the statistics of natural images.
