Browse our Research Advances

Page 38 of 52
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The modular mechanism of chromocenter formation in Drosophila

    Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita
    Cell biological study reveals the mechanism by which multiple satellite-DNA-binding proteins cooperate to form chromocenter to encapsulate the full complement of chromosomes.
    1. Cell Biology

    A systematic approach to identify recycling endocytic cargo depending on the GARP complex

    Sebastian Eising, Lisa Thiele, Florian Fröhlich
    The GARP complex is important for the endocytic recycling of amino phospholipid flippases and cell wall proteins, and thus membrane and lipid organization in yeast.
    1. Microbiology and Infectious Disease

    The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages

    Evgeniya V Nazarova, Christine R Montague ... Brian C VanderVen
    An unbiased forward genetic screen identified genes in Mycobacterium tuberculosis that are required for fatty acid import when the bacterium is residing within macrophages.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA

    Ruchika Sachdev, Maria Hondele ... Karsten Weis
    The protein Pat1 functions in the assembly of processing bodies, cellular membraneless organelles, by promoting the liquid–liquid phase separation of the DEAD-box ATPase Dhh1 and RNA.
    1. Neuroscience

    Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness

    Daan B Wesselink, Fiona MZ van den Heiligenberg ... Tamar R Makin
    fMRI results show that despite arm amputation, and varying degrees of phantom sensations, canonical hand representation in primary somatosensory cortex is largely maintained.
    1. Chromosomes and Gene Expression

    Factors affecting template switch recombination associated with restarted DNA replication

    Manisha Jalan, Judith Oehler ... Matthew C Whitby
    Genomic deletions and gene conversions, caused by template switching associated with restarted DNA replication, are detected downstream of a collapsed replication fork and are suppressed by several conserved DNA helicases.
    1. Neuroscience

    Computational modeling of brainstem circuits controlling locomotor frequency and gait

    Jessica Ausborn, Natalia A Shevtsova ... Ilya A Rybak
    A new computational model of brainstem control of locomotor speed and gait was developed to reproduce and explain recent experimental data and propose predictions for subsequent experimental testing.
    1. Neuroscience

    Neuronal morphologies built for reliable physiology in a rhythmic motor circuit

    Adriane G Otopalik, Jason Pipkin, Eve Marder
    Neurite geometry enables expansive and highly-branched neuronal structures to operate like single electrical compartments and simple linear integrators.
    1. Microbiology and Infectious Disease

    Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

    Nicole L Bertschi, Annemarie Voorberg-van der Wel ... Guglielmo Roma
    Transcriptome profiling of malaria liver-stage parasites provides unprecedented knowledge on genes and pathways expressed in truly dormant hypnozoites and indicates that dormancy is associated with a switch in energy metabolism.
    1. Neuroscience

    Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

    Michelle S Erwig, Julia Patzig ... Hauke B Werner
    Mature myelin sheaths are scaffolded by the anillin-dependent assembly of septin filaments, thereby facilitating rapid nerve conduction in the healthy CNS.