Browse our Tools and Resources

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    1. Neuroscience

    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

    Flavio H Beraldo, Daniel Palmer ... Marco AM Prado
    Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.
    1. Immunology and Inflammation

    A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

    Enas Abu-Shah, Philippos Demetriou ... Michael L Dustin
    The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.
    1. Genetics and Genomics
    2. Neuroscience

    Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation

    Ryoji Amamoto, Mauricio D Garcia ... Constance L Cepko
    Probe-Seq is a cell type specific bulk RNA sequencing method that can be applied to a wide-ranging tissue types from both vertebrates and invertebrates without genetic labeling.
    1. Neuroscience

    DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

    Jacob M Graving, Daniel Chae ... Iain D Couzin
    A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng, Franz Xaver Mittermaier ... Jörg Rolf Paul Geiger
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Cell Biology
    2. Neuroscience

    Free circular introns with an unusual branchpoint in neuronal projections

    Harleen Saini, Alicia A Bicknell ... Melissa J Moore
    A systematic study of RNA localization unexpectedly finds a set of free circular introns with a non-canonical C branchpoint enriched in neuronal projections.
    1. Cell Biology
    2. Developmental Biology

    Multiplex live single-cell transcriptional analysis demarcates cellular functional heterogeneity

    Ayhan Atmanli, Dongjian Hu ... Ibrahim John Domian
    A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

    Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz
    A facile method is implemented to modify membrane proteins with biophysical reporters using cysteine-independent approaches in live cells.
    1. Genetics and Genomics

    One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

    Wenyuan Li, Yage Zhang ... Bo Zhang
    Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
    1. Neuroscience

    DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila

    Semih Günel, Helge Rhodin ... Pascal Fua
    DeepFly3D, a deep learning-based software, measures limb and appendage movements in tethered, behaving Drosophila and enables precise behavioral measurements during neural recordings, stimulation, and other biological experiments.