Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Plant Biology

    AT-HOOK-MOTIF NUCLEAR LOCALIZED 15 extends plant longevity by binding at poorly accessible, epigenetic mark-depleted chromatin surrounding transcribed regions

    Thalia Luden, Jihed Chouaref, Remko Offringa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling

    Saurabh Thapliyal, Parvathi Sushama Gopinath, Dominique A Glauser
    Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.
    1. Genetics and Genomics

    Replicability of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Convincing
    1. Genetics and Genomics

    A retrospective analysis of 400 publications reveals patterns of irreplicability across an entire life sciences research field

    Joseph Lemaitre, Désirée Popelka ... Bruno Lemaitre
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli

    Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
    High-throughput genetics reveals all synthetic-lethal relationships for outer membrane protein biogenesis associated genes in Escherichia coli.
    1. Genetics and Genomics

    A pleiotropic EPAS1 enhancer mediating Tibetan adaptation to hypoxia is active in adipocytes

    Alexis G Thornburg, Soo-Young Park ... Marcelo A Nóbrega
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Cis-regulation and natural selection in the evolution of human DNA methylation

    Zhenzhen Ma, Alexander L Starr ... Hunter B Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Physiology

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
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Highlights

    1. Genetics and Genomics
    Microscopy image of a fruit fly. Image credit: USGS (CC0)

    How experience shapes individuality

    Bassem A Hassan
    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors