The bones in the skull of mice lacking a receptor for the structural protein, collagen, fail to elongate correctly, leading to facial defects associated with the genetic disease spondylo-meta-epiphyseal dysplasia..
The mechanism the immune system uses to prevent cytotoxic T cells from harming the body’s own cells also makes these killer cells less able to eliminate cancer.
The receptor that allows animals to taste sweet flavors can be activated by one of the ions that make up salt, suggesting that animals may experience salt as sweet.
Tracing the origin of a group of ion channels important for neuronal communication sheds light on how these proteins evolved their role in the nervous system.