A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
MARK2-mediated phosphorylation of CAMSAP2 dynamically controls Golgi orientation by altering microtubule anchoring and polarity during directional cell migration.
Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
Dip2 regulates PKC signalling through specific DAG acyl chain compositions—a crucial pathway, which emerged approximately 1.2 billion years ago, marking the advent of selective DAG-based signalling in eukaryotes.
Gene expression in nematodes during cold-induced dormancy is proposed to be regulated at the transcription level, partly involving the activation of unfolded protein response (UPR) through the IRE-1/XBP-1 signaling pathway.
Endothelial-specific supplementation with Aff3ir-ORF2 significantly ameliorated disturbed flow-induced endothelial activation and the development of atherosclerotic plaques, highlighting its promising therapeutic potential for the treatment of atherosclerosis.
