Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
VBIT-4 perturbs lipid membranes without detectably affecting VDAC1 channels or oligomerization, calling for careful interpretation of its biological effects and highlighting the need to assess membrane interactions of hydrophobic compounds.
A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
Spatial clustering of mutations in Mycobacterium tuberculosis proteins finds proteins that are involved in antibiotic resistance, and predicts which mutations cause resistance.
Saurabh Thapliyal, Parvathi Sushama Gopinath, Dominique A Glauser
Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.
The circadian photoreceptor CRYPTOCHROME selectively inhibits sleep under short winter day length by tuning down GABAergic tone within pacemaker neuron network.
Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
Two thymic macrophage subsets differ in developmental origin and specialize in apoptotic-cell clearance or immune signaling, linking the thymic myeloid niche to progression through the early β-selection-associated checkpoint.
Diverse insect movement behaviours, from scans, pirouettes, and loops to sweeping oscillations, can emerge from conserved neural circuits, with forward speed balancing goal-directed travel against exploratory sampling.
