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New evidence sheds light on actin regulation of pluripotency in human embryonic stem cells.

There are two distinct modes of late endosome fusion in the mouse yolk sac visceral endoderm cells and actin dynamics plays a role in regulating vesicle fusion.

DYRK1A, a kinase associated with intellectual developmental disorders and organ growth regulation, functions in cell growth by promoting mTORC1 activity.

A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.

Inhibitory effect on the activation of anaphase-promoting complex/cyclosome (APC/C) by MAPK Pmk1.

Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.

Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.

An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.