Browse our latest Developmental Biology articles

MMP14 activity-mediated cleavage of the ectodomain of PTH1R modulates PTH signaling in the chondrocyte-derived osteoblast lineage, regulating osteogenesis and thereby bone metabolism, with therapeutic significance for bone-wasting diseases.

OGT-mediated protein O-GlcNAcylation balances osteogenic versus adipogenic differentiation and controls hematopoietic niche function of bone marrow stromal cells.

The novel function of the evolutionarily conserved nutrient-sensing pathway TOR in the wing disc-specific autophagic degradation and development of wingless aphids.

Cells control signal circulation to set the frequency of information transmitted over tissue scales.

Spatially distinct ectodermal Wnt and endodermal Shh signals serve to polarize the skate gill skeleton.

The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.

Using the short-lived turquoise killifish, a transparent in vivo reporter line named klara is established that will be a valuable tool to explore development, senescence, aging, and regeneration.

Centriolar satellites facilitate efficient trafficking of proteins to and from centrioles and are required for early steps of cilia formation and timely ciliogenesis in vivo, where mice lacking satellites display perinatal lethality, hydrocephalus, oligospermia, and cerebellar hypoplasia.

An information theoretic and systems biology approach shows that cellular compartmentalisation and receptor promiscuity can facilitate the accurate and robust inference of position from noisy morphogen profiles, verified by experiments in Drosophila wing imaginal disc.

The mushroom body neuropils of the larval brain have regions that share neurons and functions with the adult and larval-specific regions built with 'doomed' neurons or cells that trans-differentiate for temporary larval function before assuming their adult phenotypes at metamorphosis.