Browse our latest Developmental Biology articles

β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.

Electrical synapses determine the precise position of chemical synapses in the nervous system.

Jaw joint regulatory sequence 1 (JRS1) is deeply conserved in most jawed vertebrates and displays a specific enhancer activity in the developing primary jaw joint that contributes to early nkx3.2 gene expression and jaw joint morphology.

A newly discovered enhancer region may have allowed vertebrates to evolve the ability to open and close their jaws.

SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.

C. elegans nematodes can assess faithfully the threat that H₂O₂ poses by coupling the induction of their H₂O₂ defenses to the perception of high temperature—an inherent enhancer of the reactivity of H₂O₂.

The digital 3D-atlas maker will help ascribing neuronal birthdate and neuronal differentiation times upon gene disruption in zebrafish avatars for human diseases, and will allow the integration of the information generated in other laboratories.

CEP83 plays a central role in regulating the development of intermediate mesoderm (IM) nephron progenitors, which may involve direct effects of CEP83 in the nephron progenitor differentiation program and indirect lateral plate mesoderm-mediated effects on the IM.

A meta-analysis yields a spatiotemporal map of gene expression that provides a blueprint for nematode cuticle construction and reveals novel families of cuticular intrinsically disordered proteins.

A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.