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Human antibodies that neutralize New World hantaviruses are promising for prevention or treatment of these high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact.

Serum antibodies induced by CoronaVac tended to decrease over time, even though vaccinated with the homologous booster dose, and Delta and Omicron variants may be able to more efficiently evade the antibodies with time.

A third dose of the inactivated vaccine CoronaVac fails to stimulate the production of neutralizing antibodies which target the Omicron variant.

Gene editing to generate precisely matched primary human T cell populations demonstrates that the common autoimmune risk allele in the tyrosine phosphatase, PTPN22, promotes signaling in cells expressing a low-avidity, self-reactive TCR specific for a diabetes-associated self-antigen.

The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses.

A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.

Acute lymphoblastic and myeloblastic leukemias activate lymphotoxin beta receptor in mesenchymal stem cells in the bone marrow to turn off interleukin-7 production and lymphopoiesis and gain competitive advantage.

HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.

PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.

Innate lymphoid cells type 1 suffice to induce hallmarks of alopecia areata phenotype in organ-cultured human scalp hair follicles ex vivo and in human scalp skin xenotransplants in vivo, suggesting that these cells play a role in early AA pathogenesis.