A stepped-wedge randomised controlled trial shows that early antiretroviral therapy (ART) initiation does not negatively affect the economic welfare of HIV patients in a low-income country.
Charles L Bormann, Manoj Kumar Kanakasabapathy ... Hadi Shafiee
A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.
Samuel PC Brand, Patrick Munywoki ... David James Nokes
Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.
Simone Bersini, Roberta Schulte ... Martin W Hetzer
Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
Abidemi Junaid, Johannes Schoeman ... Thomas Hankemeier
The metabolic readout of endothelial function in the microvessels-on-a-chip facilitates mechanistic studies and detection of biomarkers for microvascular diseases in a physiological relevant environment.
Phase contrast X-ray tomography based on a combination of parallel and cone beam geometry extends conventional histology by a third dimension and enables full quantication of tissue remodeling in COVID-19.
Colin Pawlowski, Tyler Wagner ... Venky Soundararajan
Longitudinal laboratory testing results tied to SARS-CoV-2 diagnostic PCR results of more than 2500 patients reveal the temporal evolution of COVID-associated coagulopathy.
Dan Valsky, Shai Heiman Grosberg ... Marc Deffains
Aberrant striatal signaling does not induce drastic changes in the spontaneous discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia.
Jesus Javier Ballesteros, Jessica Blair Briscoe, Yumiko Ishizawa
Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.