Browse our latest Stem Cells and Regenerative Medicine articles

A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.

Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.

Exposure of human cortical interneurons to hypoxia leads to decreased migration, a process that is likely altered in preterm infants and contributes to the increased risk for neurodevelopmental problems.

Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.

Branched actin cytoskeleton is critical for myoblast fusion during mouse skeletal muscle regeneration.

Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.

Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.