Browse our latest Structural Biology and Molecular Biophysics articles

A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.

Structures of the GluK2/K5 kainate receptor reveal the heteromer architecture and how the receptor organizes in apo, antagonist-bound, and desensitized states.

A single-stranded DNA binding protein stimulates helicase-mediated DNA unwinding by transiently activating a latent processivity switch in the helicase.

Archaeal histones compact DNA into nucleosome-like particles of varying sizes that contort sporadically and reorient DNA wrapping.

Time-resolved serial femtosecond crystallography revealed retinal kink and early changes in channelrhodopsin, which leads to the ion pore formation.

The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.

Structural and functional analysis of a new class of low-molecular-weight antibody fragments, derived from bovine immunoglobulins, reveals their therapeutic potential against C5, a target for refractory inflammatory diseases.

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.

The primer extension and 5' flap processing activities of DNA polymerase I are physically coordinated by combined movements of the DNA substrate and the 5' nuclease domain of the enzyme.

A chain of residues connecting the voltage sensing domain and the pore domain is responsible for a noncanonical communication between these domains.