Browse our Research Advances

Page 34 of 52
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity

    Chen Qiu, Vandita D Bhat ... Traci M Tanaka Hall
    A Caenorhabitis elegans RNA-binding protein, FBF-2, modulates RNA sequence motif recognition through conformational change and partner protein interaction.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

    Dajun Sang, Sudarshan Pinglay ... Liam J Holt
    Tight regulation of a central developmental kinase cascade evolved through two key mutations.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum

    Johannes Felix Stortz, Mario Del Rosario ... Sujaan Das
    Formin-2 controls spatiotemporal polymerisation of actin filaments, a common mechanism used by apicomplexans for effective segregation of essential chloroplast-like organelles called apicoplasts, and additionally for daughter formation in Plasmodium falciparum.
    1. Neuroscience

    The visual speech head start improves perception and reduces superior temporal cortex responses to auditory speech

    Patrick J Karas, John F Magnotti ... Michael S Beauchamp
    Human perception and brain responses differ between words, in which mouth movements are visible before the voice is heard, and words, for which the reverse is true.
    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia, Marcus Keatinge ... Dirk Sieger
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
    1. Neuroscience

    Mapping sequence structure in the human lateral entorhinal cortex

    Jacob LS Bellmund, Lorena Deuker, Christian F Doeller
    Mnemonic representations in the human anterior-lateral entorhinal cortex change through learning to reflect an experienced temporal event structure and holistic temporal maps relate to memory recall.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

    Mahmoud M Elguindy, Florian Kopp ... Joshua T Mendell
    Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
    1. Neuroscience

    Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

    Pierre-Yves Musso, Pierre Junca ... Michael D Gordon
    The Sip-Triggered Optogenetic Behavior Enclosure (STROBE) produces robust behaviors via activation of peripheral or central neurons in the fly, and mimics key features of feeding driven by chemical taste ligands.
    1. Neuroscience

    Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron

    Xiaonan Zhang, Kaylynn Coates ... Quentin Gaudry
    The activity of serotonergic neurons spanning multiple olfactory areas is regulated by both local synaptic interactions and dendrite wide computations.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

    Ben F Brian IV, Adrienne S Jolicoeur ... Tanya S Freedman
    The ubiquitin ligase c-Cbl preferentially targets unique-region phosphorylated LynA for rapid degradation, regulating its expression and differentially tuning signaling responsiveness in macrophages and mast cells.