Browse our Research Advances

Page 48 of 52
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

    Ganesan Senthil Kumar, Ezgi Gokhan ... Rebecca Page
    Building on previous work (Booth et al, 2014), we show how two mitotic phosphatases are formed, how they are regulated by opposing kinases during the cell cycle and reveal a novel opportunity for the development of cancer therapeutics.
    1. Neuroscience

    Dopaminergic neurons write and update memories with cell-type-specific rules

    Yoshinori Aso, Gerald M Rubin
    Building on previous work (Aso et al., 2014a; Aso et al., 2014b), cell-type-specific drivers and optogenetics are used to control the local release of dopamine and reveal that distinct learning rules are implemented in parallel memory units.
    1. Neuroscience

    Detection of transient synchrony across oscillating receptors by the central electrosensory system of mormyrid fish

    Alejandro Vélez, Bruce A Carlson
    Building on previous work (Baker et al., 2015), further evidence is reported for a novel mechanism for sensory coding based on the detection of oscillatory synchrony among peripheral receptors.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Updates to the zoonotic niche map of Ebola virus disease in Africa

    David M Pigott, Anoushka I Millear ... Simon I Hay
    Building on previous work (Pigott et al. 2014), estimates of areas of potential transmission of Ebola virus are revised and updated to provide a contemporary map for use by researchers and policymakers.
    1. Cell Biology

    Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis

    Wanda Kukulski, Andrea Picco ... Marko Kaksonen
    Building on previous work (Picco et al., 2015), we use a hybrid imaging approach to address the role of clathrin during endocytosis: we find that it has no role in shaping or elongating membrane invaginations, but it does contribute to the regularity of vesicle scission.
    1. Cell Biology

    In vivo super-resolution RESOLFT microscopy of Drosophila melanogaster

    Sebastian Schnorrenberg, Tim Grotjohann ... Stefan Jakobs
    Building on previous work (Grotjohann et al., 2012), low-light super-resolution microscopy has been performed on living transgenic Drosophila larvae and tissues.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors

    Yujia Cai, Anders Laustsen ... Jacob Giehm Mikkelsen
    Building on previous work (Cai et al., 2014), HIV-derived lentiviral vectors are harnessed to insert user-defined genes into a safe locus in the genome of human stem cells.
    1. Neuroscience

    Direct neural pathways convey distinct visual information to Drosophila mushroom bodies

    Katrin Vogt, Yoshinori Aso ... Hiromu Tanimoto
    Building on previous work (Vogt et al. 2014), separate visual pathways have been identified to convey information for brightness and color to the learning-related area of the Drosophila brain.
    1. Neuroscience
    2. Plant Biology

    Hawkmoths evaluate scenting flowers with the tip of their proboscis

    Alexander Haverkamp, Felipe Yon ... Danny Kessler
    Building on previous work (Kessler et al., 2015), it is shown that long-tongued hawkmoths assess individual flowers by smelling floral odors with olfactory neurons on their proboscises, and that this close-range perception is crucial for successful pollination and foraging.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

    Shaogeng Tang, Nicholas J Buchkovich ... Scott D Emr
    Building on previous work (Tang et al., 2015), novel ESCRT-III subunit Snf7 auto-activation mutants are used to reveal two parallel ubiquitin-dependent pathways during multivesicular endosome biogenesis.