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Building on previous work (Materne et al., 2015), it is shown that the ubiquitylation of histone H2B represses cell differentiation by opposing chromatin remodeling at the promoter of the master regulator of gametogenesis, ste11

Building on previous work (Lasagna-Reeves et al., 2015) it is shown that polyglutamine ATXN1 oligomers propagate locally in SCA1 mice, and that passive immunotherapy targeting soluble oligomers can lead to an improvement in motor coordination and a modest increase in life span.

Mutants of influenza A virus with increased CpG dinucleotide frequencies show restricted replication and reduced or absent pathogenicity, and powerful host innate and adaptive responses to infection that confer immunity to re-infection.

Building on previous work (Momeni et al., 2013), it is shown that recognizing the hierarchical organization of biological systems resolves the ongoing controversy on pro-cooperation mechanisms.

Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.

Building on previous work (Wang et al., 2014), we use a combination of genetic, electrophysiology and laser ablation approaches to identify a developmentally defined population of neurons that are a significant source of clinically relevant inspiratory drive to XII motoneurons.

Building on previous work (McDannald et. al, 2014), it is shown that dissociable populations of neurons in the lateral orbitofrontal cortex acquire responses to cues that predict more, less, or no change in reward in rats during training in a Pavlovian unblocking task.

Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.

Building on previous work (Stagg et al., 2014), it is shown that transcranial direct current stimulation modulates local GABA concentration and functional connectivity in the human motor cortex.

Building on previous work (Conduit et al., 2014), and contrary to what was previously thought, it is shown that key centrosomal proteins are not recruited to centrosomes as part of large multi-protein assemblies.