Browse our Short Reports

Page 29 of 64
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu, Liting Dong ... Chengqi Yi
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Computational and Systems Biology
    2. Neuroscience

    Stable task information from an unstable neural population

    Michael E Rule, Adrianna R Loback ... Timothy O'Leary
    Analysis and modelling of sensorimotor neural activity shows how ongoing plasticity and appropriately tuned weights can cope with substantial ongoing changes in the neural code.
    1. Genetics and Genomics

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo, Amy Lin ... Dudley W Lamming
    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.
    1. Computational and Systems Biology
    2. Medicine

    SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

    Praveen Anand, Arjun Puranik ... Venky Soundararajan
    SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
    1. Structural Biology and Molecular Biophysics

    Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

    Lukas M Langer, Yair Gat ... Elena Conti
    First structural view of a substrate-bound PIKK (PI3K-related-kinase) by cryo-EM explains phosphorylation specificity toward a short amino-acid motif shared across the PIKK family and rationalizes PIKK auto-inhibition by regulatory domain.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

    Aditi Banerjee, Jinoh Lee ... Pascal S Kaeser
    Genetic and electrophysiological analyses reveal calcium-triggering mechanisms for dopamine release in the striatum that may enable fast and slow dopamine coding.
    1. Plant Biology

    Lack of evidence for associative learning in pea plants

    Kasey Markel
    A fully blinded replication of the most convincing report of associative learning in plants failed to reproduce the phenomenon.
    1. Cancer Biology

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

    Caroline Contat, Pierre-Benoit Ancey ... Etienne Meylan
    In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
    1. Evolutionary Biology
    2. Neuroscience

    True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

    Francisco M Nadal-Nicolás, Vincent P Kunze ... Wei Li
    Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color detection above horizon.
    1. Neuroscience

    Whole-brain mapping of socially isolated zebrafish reveals that lonely fish are not loners

    Hande Tunbak, Mireya Vazquez-Prada ... Elena Dreosti
    Social isolation increases anti-social behaviour by altering activity in brain areas related to anxiety, stress, and reward.