Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Role of desolvation on biomolecular liquid–liquid phase separation

   Kai Zhang, Zhiyu Peng ... Wei Wang

   A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
2. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

   Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
3. 1. Neuroscience
   2. Computational and Systems Biology

   Opposite and complementary roles of the two calcium thresholds for inducing LTP and LTD in models of striatal projection neurons

   Daniel Trpevski
4. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Evolutionary remodeling of non-canonical ORF translation in mammals

   Yue Chang, Tianyu Lei ... Hong Zhang
5. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

   Simo Kitanovski, Kai Wollek, Daniel Hoffmann
6. 1. Neuroscience
   2. Computational and Systems Biology

   Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex

   Anton Pletenev, Richard T Born ... Ralf M Haefner
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   An engineered multi-step differentiation program in Escherichia coli for self-organized spatial patterning

   Emanuele Boni, Hélène Siboulet ... Yolanda Schaerli
8. 1. Computational and Systems Biology

   A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

   Jiayue Yang, James Wang, Justine Cléry

   A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.
9. 1. Computational and Systems Biology
   2. Developmental Biology

   Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

   Catherine Triandafillou, Pranav Sompalle ... Arjun Raj

   Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Opening the black box toward a modular approach to spike sorting

    Samuel Garcia, Chris Halcrow ... Pierre Yger

    Modularized spike sorting pipelines can identify performance bottlenecks, lower contribution barriers, and enable the development of highly accurate algorithms to turn extracellular recordings into spikes.