Benjamin R Thomson, Isabel A Carota ... Susan E Quaggin
Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.
Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.
In scene-selective occipital cortex and within 200 ms of processing, visual inputs are sorted according to their typical spatial position within a scene.
Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.
MmuPV1, a papillomavirus that infects laboratory mice (Mus musculus), is discovered to be sexually transmitted, providing a new animal virus model to study sexually transmitted human papillomaviruses (HPVs).
Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
