Population response magnitude predicts how well an image will be remembered, in both monkey inferotemporal cortex and neural networks trained to categorize objects.
A single-nucleotide I232T polymorphic change in FcγRIIB's transmembrane domain bends FcγRIIB's ectodomains toward cell membrane to allosterically hinder FcγRIIB's ligand association, providing novel molecular mechanism for functional loss of FcγRIIB-I232T.
The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
Jeroen Overman, Frank Fontaine ... Mathias Francois
Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
André Luiz de Oliveira, Andrew Calcino, Andreas Wanninger
Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
Hydrogen-deuterium exchange mass spectrometry reveals nucleotide-driven conformational regulation of Sec protein-channel to help impose directionality for protein transport through the Sec complex.
