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  1. Meta-Research: The changing career paths of PhDs and postdocs trained at EMBL

    Junyan Lu, Britta Velten ... Rachel Coulthard-Graf
    An analysis of the career and publication outcomes for 2284 early career researchers trained at EMBL provides insights into the evolving career landscape for life scientists.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Antibody Specificity: A strong case for third-party testing

    Fridtjof Lund-Johansen
    A strategy to identify high-quality commercially available antibodies for research reveals extensive use of non-specific antibodies and offers solutions for future large-scale testing.
    Version of Record
    Insight
    1. Neuroscience

    Anesthesia: Putting early sensory neurons to sleep

    Julia Fadjukov, Gregory Schwartz
    Neurons that transmit information from the retina to other parts of the brain are more affected by anesthesia than previously thought.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Neuroscience

    Cerebellum: Folding into shape

    Héloïse de Vareilles
    A new computational tool provides insights into the structure of the cerebellum in mammals.
    Version of Record
    Insight
    1. Medicine

    Cardiology: A new strategy for cardiac protection

    Esmaa Bouhamida, Hina W Chaudhry
    It may be possible to treat cardiac hypertrophy and injury by using drugs that inhibit a protein called SIRT2.
    Version of Record
    Insight
    1. Evolutionary Biology

    Genetics: A colourful duplication

    Violaine Llaurens
    A genetic duplication event during evolution allowed male wood tiger moths to have either yellow or white patterns on their wings.
    Version of Record
    Insight
    1. Epidemiology and Global Health
    2. Medicine

    Science Forum: Best practices to promote rigor and reproducibility in the era of sex-inclusive research

    Janet W Rich-Edwards, Donna L Maney
    Guidelines are presented to help researchers comply with sex-inclusive research mandates while upholding high standards of rigor.
    1. Genetics and Genomics
    2. Neuroscience

    Feeding: How specific molecules can lead to overeating

    María Gabriela Blanco, Diego Rayes
    A molecular pathway involving compounds found in processed foods and biogenic amines increases food intake and aging in the roundworm C. elegans.
    Version of Record
    Insight
    1. Computational and Systems Biology

    Gut Health: When diet meets genetics

    Karthickeyan Chella Krishnan
    Gene expression profiling of a diverse mouse population helps to decipher how a fat-rich diet contributes to inflammatory bowel disease.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology

    Kinase Activity: Probing conformational dynamics to understand kinase inhibition

    Ian R Outhwaite, Markus A Seeliger
    Why do some inhibitors select the on-state in ERK2, a kinase that is involved in many signaling pathways in cells, whereas others bind to more than one conformation?
    Version of Record
    Insight