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    1. Cancer Biology

    Serum, cell-free, HPV-human DNA junction detection and HPV typing for predicting and monitoring cervical cancer recurrence

    Anne R Van Arsdale, Olga Meshcheryakova ... Jack Lenz
    HPV-human DNA junction detection in serum cell-free DNA unambiguously identifies tumor genetic-signatures of integrated viral DNA from HPV-induced cancers and could be useful for recurrence prediction and monitoring residual disease.
    1. Cancer Biology
    2. Cell Biology

    Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

    Dana Naim, Zouheir Houhou ... Serge Roche
    Src-like adaptor protein (SLAP) preserves intestinal epithelial homeostasis by restraining Src-family kinase signaling, revealing a non-genetic mechanism limiting colorectal tumor initiation.
    Version of Record
    Short Report
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    • Solid
    1. Immunology and Inflammation
    2. Cancer Biology

    Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutations

    Diana Tran, Anastasiia Vaska ... Morgan Huse
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology
    2. Computational and Systems Biology

    Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibition using meta-dynamic network modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Meta Dynamic Network analysis can identify the capacity of a network to facilitate adaptive drug resistance and the respective underlying mechanistic causes.
    1. Cancer Biology

    A senescent-immune reserve niche model for incomplete lobular involution in the aging breast

    Jaida C Lue, Darren J Baker ... Derek C Radisky
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Cancer Biology

    dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors

    Zhao Sun, Qian Zhao ... Yang Fu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cancer Biology
    2. Medicine

    A novel prognostic score based on carbohydrate antigen 125, alpha-fetoprotein and carcinoembryonic antigen for Predicting postoperative prognosis in endometrial cancer: Results from a retrospective cohort study

    Zi-hao Wang, Qing Li ... Xiao-xin Ma
    1. Developmental Biology
    2. Cancer Biology

    A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlies SHH Medulloblastoma Formation

    Salsabiel El Nagar, Yinwen Liang ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Mechanical interactions at the interface of mutant and wild-type cell populations govern tissue-specific responses to oncogenic transformation in epithelia, causing mutants to be extruded, spatially restrained, or undergo persistent expansion.
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