ITCH is an important regulator of SARS-CoV-2 life cycle, coordinating ubiquitination, assembly, autophagosome-mediated secretion, and spike stability, highlighting ITCH as a promising therapeutic target for antiviral intervention.
Thomas Moss, Alexandra Wooldredge ... Shaeri Mukherjee
A phosphorylation site on Hsp70 previously linked to pathogen activity functions endogenously in DNA damage responses and connects chaperone regulation to cell cycle control.
EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
Sourav Banerjee, Nicola Minshall ... Mark Carrington
The glycosylphosphatidylinositol (GPI)-anchored receptors in Trypanosoma brucei are not confined to the flagellar pocket but instead localise across the whole cell surface, reshaping our understanding of host immune evasion and nutrient uptake.
