Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.
Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
Integration of migrasome-inspired biology with hypotonic shock-mediated vesicle generation establishes a durable and versatile platform for vaccine development.
In Toxoplasma gondii, SERCA-driven ER Ca²⁺ uptake sustains homeostasis and enables redistribution to mitochondria and other organelles, highlighting the ER as a central hub in parasite Ca²⁺ signaling and infection.
