Intermolecular steric repulsion generated by glycans on the cell membrane inhibits viral infection by preventing the formation of a virus-cell interface, regardless of the identity of molecules for glycan modification.
Mouse sperm are unable to bind the zebrafish chorion, yet a subset of hyperactivated sperm can enter and cross the micropyle, suggesting a conserved mechanism of gamete interaction across species.
Ana Teresa López-Jiménez, Dominik Brokatzky ... Serge Mostowy
High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.
Megakaryocytes form a 3D cage of laminin and collagen IV that stabilizes them within their vascular niche, while β1/β3 integrins and MMP are key regulators that assist megakaryocyte maturation and intravasation.
Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.
Alexander N Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
Fibronectin triggers secretion of extracellular vesicles carrying collagen VI that regulate smooth muscle cell adhesion and migration during vascular repair and atherogenesis.
Akinori Endo, Chikage Takahashi ... Yukiko Yoshida
Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.
