Daniel Haertter, Lara Hauke ... Christoph F Schmidt
A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
Septin-associated kinases functions in an adaptable regulatory network with overlapping functions to coordinate septin organization with actomyosin ring machinery to ensure robust cytokinesis in Saccharomyces cerevisiae.
A genome-wide RNA interference screen identified cellular processes that modulate the phase separation of a TDP-43 mutant, providing a framework for dissecting the link between its phase behavior and disease-associated aggregation.
Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel ... Nicolás Unsain
An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.
Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.
