Jaebin Kim, Edwin Bustamante ... Scott H Soderling
Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.
Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup ... Christian Kroun Damgaard
A dysregulated circular RNA in bladder cancer controls oncogenic pathways by tethering specific RNA-binding proteins, which in turn inhibits their normal functions.
N Suhas Jagannathan, Javier Yu Peng Koh ... Lisa Tucker-Kellogg
To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.
Hsp47 positively regulates the functional surface expression of endogenous GABAA receptors and plays a critical and general role in the maturation of Cys-loop neuroreceptors.
Resolving parallel and concurrent cytokine secretion is essential to studying polyfunctional cytokine-secreting cells, and to differentiating immune response granularity from unwinding the complexity and heterogeneity of cytokine responses.
Findings identify a new link between oncogenic ß-catenin and exosome biogenesis, which may serve as an important nodal point in the immune escape of hepatocellular carcinoma.
Asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates.
Rajdeep Banerjee, Thomas J Meyer ... David D Roberts
Increased extramedullary erythropoiesis in spleen compensates for the elevated turnover of red blood cells in mice lacking CD47, but extramedullary erythropoiesis is suppressed in mice lacking the CD47 ligand thrombospondin-1.
