Browse our latest Chromosomes and Gene Expression articles

Arabidopsis RNA processing factor SERRATE associates with the chromatin of intronless genes, which are usually expressed at low levels, to enhance polymerase II association.

The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.

Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.

Centromeric histones, the foundation for accurate chromosome segregation, have now been re-engineered to allow for analysis of the stoichiometry of required domains.

The Cohesin subunit Scc3 contains a hook-shaped domain that binds to DNA substrate, thus revealing that Cohesin-chromatin transactions are driven not only by topological interactions, but also by direct protein-DNA contacts.

The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.

An in vivo disulfide crosslinking assay shows preferential disassembly of nucleosomes with two H2A.Z histones by transcription machinery in yeast and conjugation to one or two ubiquitin moieties in human cells.

Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.

The deletion of Ddx6 results in the translational upregulation, but not transcript stabilization, of microRNA targets in embryonic stem cells while largely phenocopying the overall impact of global microRNA loss.

A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.