Physical gel models and numerical simulations have been created to study ferret brain gyrification and cortical malformations, while comparisons with human phenotypes aim to link genetics and brain morphogenesis.
ANKEF1 stabilizes the sperm axoneme by reinforcing the nexin–dynein regulatory complex, revealing a mechanical buffering mechanism essential for flagellar integrity and male fertility.
Stephen A Banse, Christine A Sedore ... Patrick C Phillips
Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
Mouse embryo cells undergo apical-basal polarization asynchronously at the 8-cell stage, and the timing of polarization influences subsequent lineage allocation.
Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.
