High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disrupted proteostasis is a hallmark of somatic evolution.
Differences in the ribosomal densities of the two daughters produced by a mother Escherichia coli could explain the asymmetry of aging and growth rate in previously reported such daughter pairs.
Michael James Chambers, Sophia B Scobell, Meru J Sadhu
The innate immune protein PKR, which is inhibited by viral proteins that mimic its natural substrate, has access to a wide spectrum of inhibitor-evading mutations that maintain natural substrate binding.
Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.
Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
Ageing is broadly accepted as a by-product of evolution, as thus, models allowing to conceive ageing as an adaptive force of evolution could show significant importance at a time of biogerontology mostly aiming at curing ageing.
Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
Across primates, volumes of specific brain regions relate to specific socio-ecological factors, bridging the gap between neuro-cognitive operations from laboratory studies and challenges primates face in their natural environment.
