Browse our latest Evolutionary Biology articles

Page 25 of 119
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Caspase-1 activates gasdermin A in non-mammals

    Zachary Paul Billman, Stephen Bela Kovacs ... Edward A Miao
    Amphibians, reptiles, and birds engage pyroptosis using caspase-1 and GSDMA, filling an evolutionary gap in which caspase-1 cleaves GSDME in fish and GSDMD in mammals.
    1. Evolutionary Biology
    2. Neuroscience

    Comparative neuroimaging of sex differences in human and mouse brain anatomy

    Elisa Guma, Antoine Beauchamp ... Jason P Lerch
    Comparative neuroimaging quantifies the congruence of regional neuroanatomical sex differences between humans and mice.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

    Hang Xu, Zihao Yuan ... Li Sun
    Functional divergence of caspase 3 and 7 in vertebrate is mediated by key residue mutation.
    1. Developmental Biology
    2. Evolutionary Biology

    A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis

    Jaaved Mohammed, Neha Arora ... Joanna Wysocka
    SNP-editing of human embryonic stem cells reveals cell type specific function of a genetic variant associated with changes in human jaw shape.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression plasticity followed by genetic change during colonization in a high-elevation environment

    Huishang She, Yan Hao ... Yanhua Qu
    An integrative approach allows investigations of the relationship between an initial plasticity and the subsequent adaptive evolution during rapid adaptive modification of complex systems in the wild.
    1. Evolutionary Biology

    Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation

    Tanya M Smith, Manish Arora ... Daniel R Green
    A new high-resolution approach to probing tooth chemistry shows real potential to uncover changing rainfall patterns and environmental conditions during human prehistory.
    1. Evolutionary Biology

    Computational Biology: Capturing the unpredictability of stem cells

    Arda Durmaz, Valeria Visconte
    A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.
    Version of Record
    Insight
    1. Evolutionary Biology

    Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions

    Jordan Little, Maria Chikina, Nathan L Clark
    Physical interactions are a minor contributor to the correlations in evolutionary rate over time that are observed between co-functional proteins.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice

    Thomas A Sasani, Aaron R Quinlan, Kelley Harris
    Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.