Browse our latest Genetics and Genomics articles

Page 38 of 155
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

    Ayse Kilic, Arda Halu ... Scott T Weiss
    Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Immune Response: Investigating the role of vitamin D in asthma

    Siddhant Sharma, Mayank Garg
    Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
    Version of Record
    Insight
    1. Genetics and Genomics

    Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results

    Reese Richardson, Heliodoro Tejedor Navarro ... Thomas Stoeger
    Find My Understudied Genes (FMUG) is a data-driven tool created to counteract the abandonment of understudied genes in -omics research.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Developmental Biology
    2. Genetics and Genomics

    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

    Zian Liao, Suni Tang ... Martin Matzuk
    Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.
    1. Genetics and Genomics

    Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production

    Nina K Jain, Pierce J Ogden, George M Church
    Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
    Version of Record
    Insight
    1. Genetics and Genomics

    Mitochondrial genomes of Pleistocene megafauna retrieved from recent sediment layers of two Siberian lakes

    Peter Andreas Seeber, Laura Batke ... Laura S Epp
    Abundant mitochondrial DNA of long-extinct large mammals in recent sediment of Siberian lakes suggests complex taphonomic redistribution.
    1. Genetics and Genomics

    Is competition for cellular resources a driver of complex trait heritability?

    Olivier Naret, Yuval Simons ... Jonathan K Pritchard
    Revised
    Reviewed Preprint v2
    Updated
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    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.