Browse our latest Microbiology and Infectious Disease articles

Page 74 of 180
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

    Xi Zhang, Xiaolin Zhang ... Yaling Han
    After myocardial infarction, gut microbiota affects platelet aggregation rate by regulating the absorption and metabolism of ticagrelor.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

    Francesca D'Angelo, Elena Fernández-Fueyo ... Gregory Bokinsky
    The intracellular network that distributes iron-sulfur clusters in bacteria is surprisingly 'plug and play' with iron-sulfur enzymes acquired from distantly related species, whereas the intracellular electron transfer network often needs plug adapters to connect with foreign enzymes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

    Meghan E Garrett, Jared G Galloway ... Julie M Overbaugh
    Sera from vaccinated subjects bound additional linear epitopes compared to sera from individuals with mild infection, in addition the pathways of escape from antibodies from vaccination were more uniform than those from mildly infected individuals.
    1. Microbiology and Infectious Disease

    Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

    Lei Song, Jingjing Luo ... Zhao-Qing Luo
    A novel bacterial protease activated by a eukaryote-specific factor attacks a host protein involved in cytoskeleton organization to inhibit cell migration during Legionella pneumophila infection.
    1. Microbiology and Infectious Disease

    Ribonucleotide reductase, a novel drug target for gonorrhea

    Jana Narasimhan, Suzanne Letinski ... Arthur Branstrom
    Novel small molecule inhibitors act against Neisseria including multi-drug resistant isolates by uniquely targeting RNR thereby enabling single pathogen therapy whilst sparing the microbiome.
    1. Microbiology and Infectious Disease

    Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

    R Christopher D Furniss, Nikol Kaderabkova ... Despoina AI Mavridou
    Disruption of disulfide bond formation sensitizes resistant Gram-negative bacteria expressing β-lactamases and mobile colistin resistance enzymes to currently available antibiotics.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    m6A modifications regulate intestinal immunity and rotavirus infection

    Anmin Wang, Wanyin Tao ... Shu Zhu
    RNA m6A level is dually regulated during rotavirus infection and development, METTL3 deficiency in intestinal epithelial cells results in increased resistance to rotaviral infection through reduced m6A modifications on Irf7.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution of host-microbe cell adherence by receptor domain shuffling

    EmilyClare P Baker, Ryan Sayegh ... Matthew F Barber
    Rapid evolution and gene conversion of a primate cell surface receptor family blocks recognition by pathogenic bacteria.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

    Jacob A Van Winkle, Stefan T Peterson ... Timothy J Nice
    The enteric bacterial microbiota stimulates a highly localized interferon-lambda signal within the intestinal epithelium that protects against murine rotavirus infection.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Vaccine-induced COVID-19 mimicry syndrome

    Eric Kowarz, Lea Krutzke ... Rolf Marschalek
    The Spike gene expressed by the vector-based vaccine Vaxzevria bears the risk of cryptic splicing, which in turn may lead to cellular production of soluble, instead of membrane-anchored, Spike protein variants.