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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Mechanobiology: A brighter force gauge for cells

    Victor Pui-Yan Ma, Khalid Salaita
    An improved biosensor sheds new light on tension within proteins.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Phenotypic Diversity: Setting the bar

    Charles Y Feigin, Ricardo Mallarino
    Analyzing the genomes of rock pigeons demonstrates that genetic variation comes in many forms and can have unexpected origins.
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    1. Cancer Biology

    Pancreatic Cell Fate: To be or not to be

    Zhe Zhang, Elisabeth Hessmann
    Chromatin remodeling processes can drive acinar cell fate decisions.
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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Alzheimer’s Disease: The two shapes of the Tau protein

    Jeffery W Kelly
    Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer's disease.
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    1. Cell Biology

    Cell Division: Shining light on spindle positioning

    Andrea Serra-Marques, Sophie Dumont
    Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division.
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    1. Evolutionary Biology

    Genome Evolution: We are not so special

    Zachary R Lewis, Casey W Dunn
    New sequence data from choanoflagellates improves our understanding of the genetic changes that occurred along the branch of the evolutionary tree that gave rise to animals.
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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co, Charlotte Brannon, Martin Ackermann
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Bone-Targeting Drugs: From vesicle to cytosol

    Michael J Rogers, Marcia A Munoz
    Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
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    1. Neuroscience

    Descending neurons: Disentangling the strings that organize behavior

    Matthieu Louis, Julie H Simpson
    The neurons that connect the brain and ventral nerve cord in fruit flies have been mapped in unprecedented detail.
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    1. Biochemistry and Chemical Biology

    Convergent Evolution: Shaping the import system of mitochondria

    Kostas Tokatlidis
    Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their mitochondria.
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