Browse our Research Articles

Page 52 of 1,518
    1. Evolutionary Biology

    Earliest evidence of elephant butchery at Olduvai Gorge (Tanzania) reveals the evolutionary impact of early human megafaunal exploitation

    Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
    The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
    1. Microbiology and Infectious Disease

    Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.
    1. Neuroscience

    Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain

    Hongyang Wu, Yoh Maekawa ... Hiromu Tanimoto
    Profiling endogenous Bruchpilot proteins in multiple cell types in mushroom bodies uncovered multilayered spatial configurations of active zones, from stereotyped intracellular distribution patterns to local arrangements of neighboring synapses.
    1. Neuroscience

    Formation of task representations and replay in mouse medial prefrontal cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
    Longitudinal calcium imaging in the medial prefrontal cortex reveals the emergence of de novo task representations and reward-associated replay.
    1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe
    Fd4 is expressed in NB7-1 and new-born progeny where it activates terminal selector genes to produce lineage-specific neurons.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Genetics and Genomics

    The impact of stability considerations on genetic fine-mapping

    Alan J Aw, Lionel Chentian Jin ... Yun S Song
    In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
    1. Ecology
    2. Plant Biology

    Cardenolide toxin diversity impacts monarch butterfly growth and sequestration

    Anurag A Agrawal, Amy P Hastings, Paola Rubiano-Buitrago
    Confirming coevolutionary theory, monarch butterfly caterpillars show impaired growth and toxin sequestration when feeding on realistic cardenolide mixtures from their milkweed host plants.
    1. Neuroscience

    The distinct role of human PIT in attention control

    Siyuan Huang, Lan Wang, Sheng He
    The human posterior inferotemporal cortex integrates endogenous and exogenous influences to form a unified attentional priority map for adaptive visual control.