Sandra Kleinecke, Sarah Richert ... Celia Michèle Kassmann
Dysfunctions of myelin peroxisomes cause a lysosomal storage-like disorder associated with alterations in glial and axonal membranes, which is the likely cause of nerve impairment in peroxisomal disorders.
The guide RNA and donor DNA of the CRISPR/Cas system tolerate large chemical modifications and can be engineered for enhanced delivery and gene editing.
The first inhibitor identified against an iso-enzyme that initiates O-glycosylation in the Golgi complex promises new therapeutic approaches for cancer and chronic kidney disease.
The circadian clock of Synechococcus elongatus PCC7942 schedules the activity of the transcription factor RpaA, which controls key events in carbon metabolism that contribute to cell fitness in conditions mimicking the natural environment.
The scaffold Bem1 increases the rate of GEF-mediated Cdc42 activation, while also increasing the rate and extent of GEF phosphorylation by PAK, which attenuates further scaffold stimulation.
Jean-Baptiste Raina, Peta L Clode ... David G Bourne
The intracellular location of a key sulfur compound, dimethylsulfoniopropionate, was identified in microalgae and its subsequent uptake by marine bacteria was quantified using a combination of secondary-ion mass-spectrometry techniques.
Srivatsun Sadagopan, Wilbert Zarco, Winrich A Freiwald
Disrupting the activity of the medial lateral face patch (ML) using fMRI-targeted microinjections of muscimol leads to anatomically and categorically specific impairments in a naturalistic face detection task.
Dynamic regulation of feedforward inhibition from parvalbumin-expressing inhibitory neurons is linked to the gradual restoration of cortical sensory processing following auditory nerve damage.
Ann Lin, Christopher J Giuliano ... Jason M Sheltzer
A putative therapeutic target undergoing clinical trials in breast cancer is non-essential and the drug used in those trials blocks cell division through an off-target effect.
Wenchang Zhou, Fabrizio Marinelli ... José D Faraldo-Gómez
The notion that the lumen of the ATP synthase membrane rotor is the long-sought megachannel that triggers the onset of the mitochondrial permeability transition is found to be inconsistent with its actual structural and functional properties.
