Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
The medial and lateral subdivisions of the entorhinal cortex are important for deciding "where to go from here" and "what to do to this object" in a visual context, respectively.
First two transmembrane segments of Tim17 are involved in interaction with the channel and the second two with the motor of the presequence translocase suggesting how proteins are handed over during their translocation into mitochondria.
Visual pigments with a longer peak-absorption wavelength or an open chromophore-binding pocket are generally noisier, being more prone to spontaneous activity.
Andreas J Keller, Rachael Houlton ... Fritjof Helmchen
Cortex dynamically regulates the flow of sensory information by suppressing responses of non-relevant stimuli through mechanisms of adaptation, while boosting sensory responses that are behaviorally important.
Carey D Nadell, Deirdre Ricaurte ... Bonnie L Bassler
The feedback between hydrodynamic flow conditions and biofilm spatial architecture drives competition in P. aeruginosa biofilms, and can explain variation in biofilm production observed among bacteria in natural environments.
Zfp106 functions as an RNA binding protein, binds directly to GGGGCC RNA repeats, is required in motor neurons to prevent ALS-like neurodegeneration in mice, and can suppress neurotoxicity in an established fly model of ALS.
Jeroen Overman, Frank Fontaine ... Mathias Francois
A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported.
Simon Erlendsson, Kamil Gotfryd ... Claus J Loland
Solid state NMR is unable to detect any association of substrate to the second binding site, S2, in the extracellular vestibule of the Neurotransmitter:Sodium Symporter LeuT.
