Vladislav Susoy, Erik J Ragsdale ... Ralf J Sommer
Evolutionary novelty is promoted by a macroevolutionary pulse of developmental plasticity, but is enhanced by secondary fixation, which permits developmental character release and further morphological exploration.
A new protein–protein interaction motif identified in the polarity protein and tumor suppressor Scribble, and other cortical proteins, controls their interaction with spectrins and is crucial for the localization and function of Scribble.
Stephan Heermann, Lucas Schütz ... Joachim Wittbrodt
The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
Zachary Charlop-Powers, Jeremy G Owen ... Sean F Brady
Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
Expression of the disease gene DUX4 inhibits RNA quality control in skeletal muscle, thereby stabilizing thousands of aberrant RNAs, including its own transcript.
The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
Michael Schleyer, Daisuke Miura ... Bertram Gerber
The finding that fly maggots, equipped with only 10,000 neurons, process reinforcement not only by value but also by specific quality reveals a basic operating principle of brains and challenges current models of memory organization.
Marcin Grabowicz, Dorothee Andres ... Thomas J Silhavy
A single mutation in Escherichia coli connects two essential cell envelope assembly pathways and confers vancomycin resistance by displaying molecular decoys at the cell surface.
