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mSTARR-seq identifies regions of the genome where DNA methylation causally impacts gene expression, providing a map of which epigenetic marks may influence trait variation.

Gene copy number provides more prognostic information than gene mutation status in cancer.

A robust mouse multi-tissue age predictor is presented that can be used to assess the DNA methylation age of mouse tissues and test the effects of longevity interventions.

Quantifiable bioenergetic parameters, determined from extracellular flux analyses, are distinct between macrophages infected with Mycobacteriumtuberculosis or vaccine strain M. bovis BCG, enabling assessment of future vaccine and drug efficacy.

A function-based genetic screen using the Caenorhabditis elegans axotomy model identifies new regulators and an inhibitory role for NAD⁺ in axon regeneration, expanding the understanding of axon injury responses and regeneration.

A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.

A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.

RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.

A bright and stochastic multicolor labeling method, Tetbow, facilitates millimeters-scale reconstructions of neuronal circuits at a large scale using tissue clearing.

FIB-SEM is used to identify comprehensively and reconstruct 192 neurons and their complete connectome for glomerulus VA1v of the Drosophila antennal lobe, in particular to reconstruct its local interneurons.