Browse the latest research

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    1. Plant Biology

    Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway

    Ravi Shankar Ojha, Marius Theune ... Kirstin Gutekunst
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    The cow udder is a potential coinfection site for influenza A viruses

    Rute Maria Pinto, Colin P Sharp ... Paul Digard
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    A Functional Influence Based Circuit Motif That Constrains the Set of Plausible Algorithms of Cortical Function

    Anna Vasilevskaya, Georg B Keller
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology
    2. Computational and Systems Biology

    Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibition using meta-dynamic network modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Meta Dynamic Network analysis can identify the capacity of a network to facilitate adaptive drug resistance and the respective underlying mechanistic causes.
    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.
    1. Ecology
    2. Evolutionary Biology

    Evolution of sideways locomotion in crabs

    Junya Taniguchi, Tsubasa Inoue ... Yuuki Kawabata
    Sideways locomotion in true crabs likely originated once from a forward-moving ancestor, providing insight into how behavioral innovations shape evolutionary diversification.
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Neuroscience

    HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neurocognitive Modeling

    Alexander Fengler, Yang Xu ... Michael J Frank
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete