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Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.

A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.

Invasive Lantana camara exhibits strong genetic structure, unlike many invasive species, likely driven by predominant self-fertilization across its invasive range rather than the presence of multiple species.

The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.

Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.

Humans adapt learning rates on both a fast and a slow time scale, and the central orbitofrontal cortex may represent the slow time scale.

Double-knockout of PKMζ and the other atypical PKC, PKCι/λ, reveals that, without PKMζ for maintenance, PKCι/λ becomes persistently active to sustain hippocampal late-LTP and long-term memory.