Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
Jonathan Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
Automated, long-term tracking reveals that social rank in male mice is a stable individual trait that persists across group changes, with chasing serving to negotiate rank among dominant individuals.
Meta Dynamic Network analysis can identify the capacity of a network to facilitate adaptive drug resistance and the respective underlying mechanistic causes.
Hélène Vantomme, Valentin Quiniou ... David Klatzmann
Sex-specific biases in thymic T cell receptor selection enrich female CD8 T cell repertoires for autoimmunity-associated self-antigens, helping explain women’s increased susceptibility to autoimmune diseases.
