Browse our latest Computational and Systems Biology articles

Visualizations, simulations, and examples are used to provide an accessible synthesis of the reasoning and assumptions behind commonly used causal discovery approaches.

Loss of nonstationary connectivity in a subcortical fronto-temporoparietal network distinguishes patients with minimal conscious state and unresponsive wakefulness state, strongly supporting the mesocircuit hypothesis.

Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.

A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.

Precisely tracking the anatomical sources of neural computations infers functional directed connectivity between hippocampal memory neurons and cortical sensory neurons, it reveals information flowing from cortex to hippocampus during encoding but the reverse direction during maintenance.

Kombucha tea microbiome analysis demonstrates the identification, characterization and extrapolation of minimal cores as a promising framework for mechanistic investigation of microbiome behaviors.

Reducing the microbial diversity in a type of fermented tea reveals the core metabolic interactions responsible for the drink’s signature taste and characteristics.

Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.

A mathematical model of osteoporosis explains why the sequence of osteoporosis medications matters for short-term and long-term treatment success.

Behavioural evidence and computational analyses suggest that people tend to decline the pursuit of more rewarded goals because they, wrongly, expect them to require more effortful actions.