Browse our latest Computational and Systems Biology articles

Page 55 of 131
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Towards a unified model of naive T cell dynamics across the lifespan

    Sanket Rane, Thea Hogan ... Andrew J Yates
    Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.
    1. Computational and Systems Biology
    2. Neuroscience

    Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice

    Romane Cecchi, Fabien Vinckier ... Julien Bastin
    Invasive electrophysiological recordings from the human brain reveal that different mood levels translate into different brain states that predispose subjects to make risky or safe decisions.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Adaptive Immunity: Maintaining naivety of T cells

    Ken Duffy
    Mathematical models encoding biological hypotheses reveal new insight into the dynamics of naive immune cells in mice from birth to old age.
    Version of Record
    Insight
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Bayesian inference of kinetic schemes for ion channels by Kalman filtering

    Jan L Münch, Fabian Paul ... Klaus Benndorf
    For analyzing time-dependent patch-clamp or patch-clamp fluorometry data of ion channels in terms of Markovian models, the superiority of Bayesian filtering with respect to traditional deterministic approaches is demonstrated enabling more reliable quantification of the parameters.
    1. Computational and Systems Biology
    2. Neuroscience

    The geometry of robustness in spiking neural networks

    Nuno Calaim, Florian A Dehmelt ... Christian K Machens
    Spiking neural networks become robust to various perturbations of their parameters if their voltages are confined to a lower-dimensional subspace, and both dynamics and robustness can be visualised in this voltage subspace.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A biophysical threshold for biofilm formation

    Jenna A Moore-Ott, Selena Chiu ... Sujit S Datta
    A biophysical model of the process by which bacteria transition from the motile planktonic state to the immobilized biofilm state yields testable predictions in terms of two dimensionless parameters, one describing nutrient availability and the other describing cellular dispersal.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Bacteria: To biofilm or not to biofilm

    Shravan Pradeep, Paulo E Arratia
    A new model helps to predict under which conditions a species of bacteria will switch to a static lifestyle.
    Version of Record
    Insight
    1. Computational and Systems Biology

    Meta-Research: How parenthood contributes to gender gaps in academia

    Xiang Zheng, Haimiao Yuan, Chaoqun Ni
    Gender gaps in academic achievement are in fact "parenthood gender gaps", with mothers experiencing higher levels of work-family conflict, and receiving lower levels of partner support, than fathers.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Cell Culture: Implementing robotics and artificial intelligence

    Sujith Sebastian
    An automated platform for cell culture combines robotics and artificial intelligence to optimize cell culture protocols and reliably produce specific cell types that could be used for regenerative medicine treatments.
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    Insight
    1. Computational and Systems Biology

    Inferring characteristics of bacterial swimming in biofilm matrix from time-lapse confocal laser scanning microscopy

    Guillaume Ravel, Michel Bergmann ... Simon Labarthe
    A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.