Browse our latest Epidemiology and Global Health articles

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    1. Epidemiology and Global Health

    Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites

    Qianxi Feng, Eric Nickels ... Joseph L Wiemels
    Familial cancer clustering was significantly higher in US minority populations compared to those of US European origin, suggesting renewed need for a focus on family cancer predisposition in US Latinos, Blacks, and Asian/Pacific Islanders.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

    Eme Ekeng, Serges Tchatchouang ... Shirlee Wohl
    The T12 Vibrio cholerae lineage has been continuously circulating in West Africa since at least 2012, highlighting the importance of regional disease control efforts.
    1. Epidemiology and Global Health
    2. Medicine

    A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs

    Eyad A Qunaibi, Mohamed Helmy ... Iyad Sultan
    Providing important data regarding the proportion of COVID-19 vaccine hesitancy and barriers toward vaccination in Arabic-speaking people to guide addressing the problem and achievement of widespread vaccination and collective immunity.
    1. Epidemiology and Global Health

    Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality

    Arturo Casadevall, Quigly Dragotakes ... Rickey E Carter
    A population-level analysis of convalescent plasma use and COVID-19 mortality in the USA revealed an inverse correlation and an estimate that recent declines in plasma use could have resulted in about 30,000 excess deaths.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart, Philip K Maini, Robin N Thompson
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke, Michael Powell ... Susan Athey
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
    1. Epidemiology and Global Health

    Alcohol consumption in the general population is associated with structural changes in multiple organ systems

    Evangelos Evangelou, Hideaki Suzuki ... Paul Elliott
    The results imply that there is not a safe threshold below which there are no toxic effects of alcohol.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill, Christian E Gunning ... Pejman Rohani
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Epidemiology and Global Health
    2. Medicine

    Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

    Heli Julkunen, Anna Cichońska ... Nightingale Health UK Biobank Initiative
    Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén, Mark Clements ... Gustaf Edgren
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.